Lymph node reactivity and microvessel density in neck metastases of unknown primary squamous cell carcinoma
| Autor: | Allan Fernando Giovanini, Onivaldo Cervantes, Marilene Paladino Rosas, Ali Amar |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.medical_treatment CD34 pathologic neovascularization Disease-Free Survival Metastasis head and neck neoplasms lymph nodes squamous cell cancer medicine Humans Lymph node Microvessel Retrospective Studies Neovascularization Pathologic business.industry Microcirculation Neck dissection Hyperplasia Middle Aged medicine.disease Desmoplasia medicine.anatomical_structure unknown primary neoplasms Otorhinolaryngology Carcinoma Squamous Cell Neoplasms Unknown Primary Lymph medicine.symptom business |
| Zdroj: | Brazilian Journal of Otorhinolaryngology. 72(3):382-386 |
| ISSN: | 1808-8694 |
| DOI: | 10.1016/s1808-8694(15)30973-3 |
| Popis: | Summary Background neoangiogenesis and the immune response are important mechanisms in metastasis development. Aim to evaluate lymph node reactivity and microvessel density in neck metastasis of occult primary squamous cell carcinoma considering their histological and clinical variables. Study design retrospesctive case-series. Method 19 patients with neck metastasis of occult primary squamous cell carcinoma who underwent neck dissection between 1983 and 2000 were selected. The lymph nodes were reevaluated on the type of reactivity in both the cortical and paracortical areas, and the metastasis were assessed as to grade, desmoplasia, necrosis and microvessel density (CD34). The relationship between histological and clinical variables was evaluated. Results the median microvessel density was 91 vessels/mm2, varying from 28 to 145. Paracortical hyperplasia was more common in patients below 55 years of age (90% x 44%, p=0.05), but there was no relationship between reactivity patterns and microvessel density with prognosis. The disease-free survival was 52% in 3 years, being similar in both groups, with higher or lower microvessel densities. Conclusion microvessel density in neck metastasis of occult primary squamous cell carcinoma had a great individual variability. It wasn't possible to establish the relationship between microvessel density and the clinical or histological variables studied. |
| Databáze: | OpenAIRE |
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