Grey matter OPCs are less mature and less sensitive to IFN gamma than white matter OPCs
| Autor: | Wia Baron, Dennis H Lentferink, Inge L. Werkman, Jacomien M Jongsma |
|---|---|
| Přispěvatelé: | Molecular Neuroscience and Ageing Research (MOLAR) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
MONOCLONAL-ANTIBODY Central nervous system CUPRIZONE-INDUCED DEMYELINATION lcsh:Medicine Grey matter Biology Antiviral Agents Article White matter 03 medical and health sciences Myelin 0302 clinical medicine OLIGODENDROCYTE PROGENITOR CELLS CORTICAL REMYELINATION medicine Animals Interferon gamma Remyelination Gray Matter lcsh:Science Cells Cultured TUMOR-NECROSIS-FACTOR Multidisciplinary INTERFERON-GAMMA Regeneration (biology) Multiple sclerosis Stem Cells lcsh:R CENTRAL-NERVOUS-SYSTEM MULTIPLE-SCLEROSIS LESIONS FACTOR-ALPHA Cell Differentiation medicine.disease White Matter Nerve Regeneration Rats MYELINATING OLIGODENDROCYTES Oligodendroglia 030104 developmental biology medicine.anatomical_structure lcsh:Q Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018) Scientific Reports, 8(1):2113. Nature Publishing Group |
| ISSN: | 2045-2322 |
| Popis: | Multiple sclerosis (MS) is a chronic inflammatory disease characterized by the formation of demyelinated lesions in the central nervous system. At later stages of the disease repair in the form of remyelination often fails, which leads to axonal degeneration and neurological disability. For the regeneration of myelin, oligodendrocyte progenitor cells (OPCs) have to migrate, proliferate and differentiate into remyelinating oligodendrocytes. Remyelination occurs faster and is more extensive in grey matter (GM) lesions than in white matter (WM) lesions. Here, we examined differences in neonatal OPCs from GM (gmOPCs) and WM (wmOPCs), both intrinsically and in response to environmental (injury) signals. We show that gmOPCs are less mature than wmOPCs, both on morphological and on gene-expression level. Additionally, gmOPCs proliferate more and differentiate slower than wmOPCs. When exposed to astrocyte-secreted signals wmOPC, but not gmOPC, migration decreases. In addition, wmOPCs are more sensitive to the detrimental effects of IFNγ treatment on proliferation, differentiation, and process arborisation, which is potentiated by TNFα. Our results demonstrate that OPCs from GM and WM differ both intrinsically and in response to their environment, which may contribute to the difference in remyelination efficiency between GM and WM MS lesions. |
| Databáze: | OpenAIRE |
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