Self-contracting oxidized starch/gelatin hydrogel for noninvasive wound closure and wound healing
| Autor: | Kun Yu, Ruiqi Xie, Mao Qin, Oskar Hoffmann, Fangyin Dai, Songmin Shang, Fei Lu, Guangqian Lan |
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| Rok vydání: | 2020 |
| Předmět: |
Skin staplers
Materials science food.ingredient Starch 02 engineering and technology Noninvasive 010402 general chemistry 01 natural sciences Gelatin chemistry.chemical_compound food Dermis lcsh:TA401-492 medicine Self-contracting General Materials Science Suture integumentary system Mechanical Engineering 021001 nanoscience & nanotechnology 0104 chemical sciences medicine.anatomical_structure chemistry Mechanics of Materials Wound dressing Shape memory hydrogel lcsh:Materials of engineering and construction. Mechanics of materials Wound closure Sutured wounds 0210 nano-technology Wound healing Biomedical engineering |
| Zdroj: | Materials & Design, Vol 194, Iss, Pp 108916-(2020) |
| ISSN: | 0264-1275 |
| DOI: | 10.1016/j.matdes.2020.108916 |
| Popis: | Major challenges in traditional wound closure methods (e.g. using sutures and skin staplers) remain inadequately unaddressed; these invasive treatments induce extra puncture wounds, anesthetic side effects, and severe scarring. Herein, an oxidized starch/gelatin-based shape memory hydrogel (OSG) was fabricated as a self-contracting wound dressing to facilitate noninvasive wound closure. The self-contracting properties were attributed by introducing crosslink net-points in the hydrogel polymer structure through Schiff base reaction between oxidized starch (OS) and gelatin. We systematically investigated the self-contracting properties to determine the feasibility of the hydrogel to treat wounds and promote wound closure noninvasively. Following elongation, OSGs could be entirely fixed in a temporary shape at 4 °C, and then contracted under infrared irradiation (IR) for shape memory activation near human physiological temperature (38 °C), providing sufficient recovery force (4 kPa) for successful noninvasive wound closure. Additionally, H&E staining revealed that thicker epidermis and dermis layers were achieved upon OSG treatment, confirming that the OSG facilitated tissue reconstruction in an in vivo rabbit model. Moreover, the OSG-treated wounds displayed smoother skin and no visible scarring compared to sutured wounds. Such excellent performance suggests that OSG hydrogel exhibits high potential as an alternative to medical sutures to facilitate noninvasive would closure. |
| Databáze: | OpenAIRE |
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