Blood Biomarkers to Predict Long-Term Mortality after Ischemic Stroke
| Autor: | Laura Ramiro, Blanca Lara, Josep Zaragoza, Estevo Santamarina, Laura Abraira, Mikel Terceño, Alejandro Bustamante, Xavier Ustrell, José Alvarez-Sabín, Manuel Quintana, María Hernández-Pérez, Paula García-Rodríguez, Joan Montaner |
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| Přispěvatelé: | Institut Català de la Salut, [Ramiro L, García-Rodríguez P] Neurovascular Research Laboratory, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Abraira L, Quintana M, Santamarina E] Unitat d’Epilèpsia, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Álvarez-Sabín J] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Montaner J] Neurovascular Research Laboratory, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC/University of Seville & Department of Neurology, Hospital Universitario Virgen Macarena, Seville, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Rok vydání: | 2021 |
| Předmět: |
Multivariate analysis
endostatin 030204 cardiovascular system & hematology factores biológicos::biomarcadores [COMPUESTOS QUÍMICOS Y DROGAS] 0302 clinical medicine TNF-R1 Ischemia Risk of mortality Isquèmia lcsh:Science Stroke Ischemic stroke biology Biochemical markers Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Brain Ischemia [DISEASES] Quartile Marcadors bioquímics Biomarker (medicine) biomarker Endostatin medicine.medical_specialty Prognosi Biological Factors::Biomarkers [CHEMICALS AND DRUGS] General Biochemistry Genetics and Molecular Biology Article enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::isquemia cerebral [ENFERMEDADES] 03 medical and health sciences Internal medicine Other subheadings::Other subheadings::Other subheadings::/mortality [Other subheadings] medicine ischemic stroke Mortalitat cardiovascular diseases Mortality Interleukin 6 Diagnosis::Prognosis [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] diagnóstico::pronóstico [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Ecology Evolution Behavior and Systematics IL-6 Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad [Otros calificadores] business.industry Proportional hazards model Paleontology Biomarker medicine.disease mortality Space and Planetary Science biology.protein Isquèmia cerebral - Mortalitat lcsh:Q business 030217 neurology & neurosurgery |
| Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Dipòsit Digital de la UB Universidad de Barcelona Life Scientia Life, Vol 11, Iss 135, p 135 (2021) Volume 11 Issue 2 |
| Popis: | Stroke is a major cause of disability and death globally, and prediction of mortality represents a crucial challenge. We aimed to identify blood biomarkers measured during acute ischemic stroke that could predict long-term mortality. Nine hundred and forty-one ischemic stroke patients were prospectively recruited in the Stroke-Chip study. Post-stroke mortality was evaluated during a median 4.8-year follow-up. A 14-biomarker panel was analyzed by immunoassays in blood samples obtained at hospital admission. Biomarkers were normalized and standardized using Z-scores. Multiple Cox regression models were used to identify clinical variables and biomarkers independently associated with long-term mortality and mortality due to stroke. In the multivariate analysis, the independent predictors of long-term mortality were age, female sex, hypertension, glycemia, and baseline National Institutes of Health Stroke Scale (NIHSS) score. Independent blood biomarkers predictive of long-term mortality were endostatin > quartile 2, tumor necrosis factor receptor-1 (TNF-R1) > quartile 2, and interleukin (IL)-6 > quartile 2. The risk of mortality when these three biomarkers were combined increased up to 69%. The addition of the biomarkers to clinical predictors improved the discrimination (integrative discriminative improvement (IDI) 0.022 (0.007–0.048), p < 0.001). Moreover, endostatin > quartile 3 was an independent predictor of mortality due to stroke. Altogether, endostatin, TNF-R1, and IL-6 circulating levels may aid in long-term mortality prediction after stroke. |
| Databáze: | OpenAIRE |
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