Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer
| Autor: | Benita Tan, Aye Aye Thike, Ana Richelia Jara-Lazaro, Patrick Tan, Puay Hoon Tan, Poh Yian Cheok |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
CA15-3 Oncology medicine.medical_specialty Pathology medicine.drug_class Breast Neoplasms Sensitivity and Specificity Pathology and Forensic Medicine Basal (phylogenetics) Breast cancer Internal medicine Biomarkers Tumor Humans Medicine Pathological Triple-negative breast cancer biology business.industry CD117 Cancer Genes erbB-2 Middle Aged medicine.disease Immunohistochemistry ROC Curve Receptors Estrogen Tissue Array Analysis Estrogen Area Under Curve biology.protein Keratins Female Receptors Progesterone business |
| Zdroj: | Modern Pathology. 23:123-133 |
| ISSN: | 0893-3952 |
| DOI: | 10.1038/modpathol.2009.145 |
| Popis: | Triple-negative breast cancer, defined as that with negative expression of estrogen and progesterone receptors and cerbB2, accounted for 11% of invasive breast cancers in our study, drawn from an original cohort of 7048 women diagnosed with breast cancer from the files of the Department of Pathology, Singapore General Hospital, over 14 years. Women with triple-negative breast cancer were generally postmenopausal, with adverse pathological characteristics of high histological grade and frequent nodal metastases. Using a set of 61 invasive breast cancers earlier profiled into molecular subtypes with expression arrays, we defined specificity and sensitivity values for different immunohistochemical panels of basal keratins (CK5/6, CK14, CK17, 34 beta E12), CD117, EGFR, p63 and SMA in defining basal-like breast cancer. Subsequent application of a tri-panel of CK14, EGFR and 34 beta E12 (specificity 100% and sensitivity 78%) to our group of 653 triple-negative breast cancers delineated 84% to be basal-like. Immunohistochemical expression of individual biological markers correlated with unfavorable pathological parameters. We conclude that triple-negative breast cancers in an Asian population harbor adverse pathobiological features, and an immunohistochemical surrogate panel can be reliably used to define basal-like cancers among them. |
| Databáze: | OpenAIRE |
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