Changes in Neonatology: Comparison of Two Cohorts of Very Preterm Infants (Gestational Age <32 Weeks): The Project on Preterm and Small for Gestational Age Infants 1983 and The Leiden Follow-Up Project on Prematurity 1996-1997
| Autor: | Sylvia Veen, Gerlinde M. S. J. Stoelhorst, Ronald Brand, Shirley E. Martens, A. Lya Den Ouden, M. Rijken, J.M. Wit |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Infant Premature Diseases Cohort Studies Intensive Care Units Neonatal Infant Mortality medicine Humans Infant Very Low Birth Weight Hospital Mortality Neonatology Prospective cohort study Bronchopulmonary Dysplasia Netherlands Respiratory Distress Syndrome Newborn Respiratory distress business.industry Infant Newborn Gestational age Length of Stay Delivery Obstetric medicine.disease Obstetrics Socioeconomic Factors Bronchopulmonary dysplasia Premature birth Infant Small for Gestational Age Pediatrics Perinatology and Child Health Premature Birth Small for gestational age Female business Infant Premature Follow-Up Studies Cohort study |
| Zdroj: | Pediatrics. 115:396-405 |
| ISSN: | 1098-4275 0031-4005 |
| Popis: | Objective. To determine changes in peri- and neonatal care concerning neonatal mortality and morbidity by comparing 2 cohorts of very prematurely born infants (gestational age [GA] Methods. The Leiden Follow-Up Project on Prematurity (LFUPP-1996/97), a regional, prospective study, includes all infants who were born alive after a GA Results. The absolute number of preterm births in the study region increased by 30%: 102 in 1983 to on average of 133 in 1996–1997. Centralization of perinatal care improved: the percentage of extrauterinely transported infants decreased from 61% in 1983 to 35% in 1996–1997. A total of 182 (73%) of the LFUPP-1996/97 infants were treated antenatally with glucocorticosteroids compared with 6 (6%) of the POPS-1983 infants. A total of 112 (42%) of the LFUPP-1996/97 infants received surfactant. In-hospital mortality decreased from 30% in the 1980s to 11% in the 1990s. Mortality of the extremely preterm infants (Conclusions. An increase in the absolute number of very preterm births in this study region was found, leading to a greater burden on the regional NICUs. Improvements in peri- and neonatal care have led to an increased survival of especially extremely preterm infants. However, increased survival has resulted in more morbidity, mainly bronchopulmonary dysplasia, at the moment of discharge from the hospital. |
| Databáze: | OpenAIRE |
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