Cancellous bone resorption in the proximal ilium of the ovariectomized rat
| Autor: | M. W. J. Ferguson, D. H. Carter, H. Devlin |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Chemistry
Osteoid Ovariectomy Endocrinology Diabetes and Metabolism Osteoclasts Cell Count Rats Inbred Strains Anatomy Bone resorption Rats Resorption Ilium Trabecular bone Endocrinology medicine.anatomical_structure Osteoclast medicine Ovariectomized rat Animals Female Orthopedics and Sports Medicine Bone Resorption Cancellous bone Tissue volume |
| Zdroj: | Calcified Tissue International. 46:395-400 |
| ISSN: | 1432-0827 0171-967X |
| DOI: | 10.1007/bf02554970 |
| Popis: | Bone histomorphometry was performed on the proximal ilium of mature Sprague-Dawley rats following ovariectomy, and these rats were compared with sham-operated controls. Bone volume per unit tissue volume (BV/TV), osteoid surface, and the depth and extent of eroded cavities were measured in animals killed at intervals after operation. The rate of bone loss and the mean osteoid surface in the proximal ilium of the ovariectomized rats was significantly greater than that of the control rats over a 210-day postoperative period. The eroded surface and mean trabecular thickness in the proximal ilium of the ovariectomized rats were not significantly different from that of the control rats, and therefore failed to explain the difference in the rate of bone loss. The distribution of the depths of trabecular eroded cavities in the ilium of ovariectomized rats was different from that in the control rats. The loss of trabecular bone mass in the proximal ilium of ovariectomized, mature rats appeared due to increased activity of individual osteoclasts, rather than to increased osteoclast numbers and thinning of trabeculae. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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