Correlation of glioma proliferation assessed by flow cytometry with 99mTc-Tetrofosmin SPECT uptake

Autor: Athanasios Papadopoulos, Andreas Fotopoulos, Athanasios P. Kyritsis, George A. Alexiou, Spyridon Tsiouris, George Vartholomatos, George Fotakopoulos, Spyridon Voulgaris
Rok vydání: 2009
Předmět:
Male
tc-99m-mibi
Pathology
brain-tumors
99mTc-tetrofosmin
spect
Pilot Projects
Correlation
glioma
Image Processing
Computer-Assisted
Prospective Studies
grade
medicine.diagnostic_test
Brain Neoplasms
Glioma
Organotechnetium Compounds
General Medicine
Middle Aged
Cell cycle
Flow Cytometry
cell nuclear antigen
tetrofosmin
DNA-content
Female
medicine.medical_specialty
DNA/genetics
Flow cytometry
Central nervous system disease
Organophosphorus Compounds
medicine
Humans
Gamma Cameras
tc-99m-sestamibi
Radiopharmaceuticals/*diagnostic use
Aged
Cell Proliferation
Tomography
Emission-Computed
Single-Photon
Brain Neoplasms/genetics/*pathology/*radionuclide imaging
Organophosphorus Compounds/*diagnostic use
business.industry
flow cytometry
glioblastoma
DNA
Aneuploidy
medicine.disease
Glioma/genetics/*pathology/*radionuclide imaging
Glioblastoma/pathology/radionuclide imaging
tl-201
Surgery
Organotechnetium Compounds/*diagnostic use
Neurology (clinical)
Radiopharmaceuticals
Glioblastoma
business
(99m)tc-tetrofosmin spect
Emission computed tomography
Anaplastic astrocytoma
Zdroj: Clinical Neurology and Neurosurgery. 111:808-811
ISSN: 0303-8467
DOI: 10.1016/j.clineuro.2009.08.009
Popis: Objectives: Brain single-photon emission computed tomography (SPECT) has been proposed as a potentially useful modality for the metabolic assessment of various brain tumors. Material and methods: In a 10-patient prospective pilot study we evaluated whether (99m)Tc-Tetrofosmin ((99m)Tc-TF) uptake correlates with glioma proliferative activity assessed by flow cytometric analysis. (99m)Tc-TF brain SPECT was performed shortly before surgical tumor excision. Results: Eight patients were diagnosed with glioblastoma multiform and 2 with anaplastic astrocytoma. All tumors were aneuploid. We found a significant positive linear correlation between 99mTc-TF uptake and percentage of tumor cells on the S-phase of the cell cycle (r=0.92, P=0.001). Conclusion: Initial evidence suggests that 99mTc-TF could provide a non-invasive indicator of glioma proliferative activity. (C) 2009 Elsevier B.V. All rights reserved. Clin Neurol Neurosurg
Databáze: OpenAIRE
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