Adolescence and Aging: Impact of Adolescence Inflammatory Stress and Microbiota Alterations on Brain Development, Aging, and Neurodegeneration
| Autor: | Nour Yahfoufi, Nafissa Ismail, Chantal Matar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Aging
Adolescent Disease Gut flora AcademicSubjects/MED00280 Neurochemical Neuroinflammation medicine Humans Microbiome Neurodegeneration Special Issue: The Gut Microbiome and Aging Depression (differential diagnoses) Inflammation biology business.industry Microbiota Puberty Brain Neurodegenerative Diseases medicine.disease biology.organism_classification Adolescence Gastrointestinal Microbiome AcademicSubjects/SCI00960 Geriatrics and Gerontology business Dysbiosis Neuroscience Stress Psychological |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences |
| ISSN: | 1758-535X 1079-5006 |
| Popis: | Puberty/adolescence is a critical phase during neurodevelopment with numerous structural, neurochemical, and molecular changes occurring in response to genetic and environmental signals. A consequence of this major neuronal reorganizing and remodeling is a heightened level of vulnerability to stressors and immune challenges. The gut microbiota is a fundamental modulator of stress and immune responses and has been found to play a role in mental health conditions and neurodegenerative disorders. Environmental insults (stress, infection, neuroinflammation, and use of antibiotics) during adolescence can result in dysbiosis subsidizing the development of brain disorders later in life. Also, pubertal neuroinflammatory insults can alter neurodevelopment, impact brain functioning in an enduring manner, and contribute to neurological disorders related to brain aging, such as Alzheimer’s disease, Parkinson’s disease, and depression. Exposure to probiotics during puberty can mitigate inflammation, reverse dysbiosis, and decrease vulnerabilities to brain disorders later in life. The goal of this review is to reveal the consequences of pubertal exposure to stress and immune challenges on the gut microbiota, immune reactivity within the brain, and the risk or resilience to stress-induced mental illnesses and neurodegenerative disorders. We propose that the consumption of probiotics during adolescence contribute to the prevention of brain pathologies in adulthood. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|