Effects of marathon race on selected myokines and sclerostin in middle-aged male amateur runners
Autor: | Ewa Śliwicka, Tomasz Cisoń, Łucja Pilaczyńska-Szcześniak, Anna Straburzyńska-Lupa, Andrzej Ziemba |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Science Parathyroid hormone 030209 endocrinology & metabolism Marathon Running Myostatin Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Osteoprotegerin Bone Density Internal medicine Myokine medicine Endocrine system Humans Muscle Skeletal Adaptor Proteins Signal Transducing Bone mineral Multidisciplinary biology business.industry Middle Aged Hormones Fibronectins 030104 developmental biology Endocrinology chemistry Parathyroid Hormone biology.protein Body Composition Sclerostin Medicine Cytokines business Homeostasis |
Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
ISSN: | 2045-2322 |
Popis: | In recent years, there has been increasing interest in the homeostatic response to extreme exercises, especially in the integrated function of muscle and bone. The aim of this study was to evaluate the effects of a marathon race on selected myokines and sclerostin in 10 male recreational runners (mean age 41 ± 7.7 years). Body composition, bone mineral density (BMD), and the serum concentration of myostatin, irisin, sclerostin, osteoprotegerin (OPG), 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), high-sensitivity interleukin-6 (hsIL-6), tumor necrosis factor α (TNFα), high-sensitivity C-reactive protein (hsCRP) and myoglobin, were determined 24 h before and 24 h and 72 h after a marathon race. Post-marathon increases were observed in the levels of myostatin (1.2-fold), OPG (1.5-fold), and PTH (1.3-fold), hsIL-6 (1.9-fold), myoglobin (4.1-fold), hsCRP (fivefold), TNFα (2.6-fold), after 24 h; and in myostatin (1.2-fold), irisin (1.1-fold), sclerostin (1.3-fold), OPG (1.3-fold), and PTH (1.4-fold), hsIL-6 (1.4-fold), TNFα (1.9-fold), after 72 h compared to the baseline level. The results show that in response to the marathon run, a complex network of endocrine interactions is initiated. Further research is needed to fully elucidate the long-term impact of prolonged high intensity exercise on the human body. |
Databáze: | OpenAIRE |
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