v-myb and v-ets cooperate for the mitogenic stimulation of primary fibroblasts by avian E26 retrovirus
| Autor: | Bertrand Pain, Pierre Jurdic, D Leprince, D Stehelin, R Li, C Domenget, Jacques Samarut, P Ravel-Chapuis |
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| Přispěvatelé: | Unité mixte de recherche biologie moléculaire de la cellule, École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), ProdInra, Migration, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-École normale supérieure - Lyon (ENS Lyon) |
| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
[SDV]Life Sciences [q-bio]
DNA Mutational Analysis Restriction Mapping Retroviridae Proteins Oncogenic Immunology Stimulation Chick Embryo In Vitro Techniques Biology medicine.disease_cause Microbiology DNA-binding protein Structure-Activity Relationship 03 medical and health sciences Retrovirus Virology medicine Animals MYB Fibroblast Cells Cultured ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Mutation Avian Leukosis Virus Oncogene Cell growth 030302 biochemistry & molecular biology Nuclear Proteins biology.organism_classification Molecular biology Oncogene Proteins v-myb 3. Good health DNA-Binding Proteins [SDV] Life Sciences [q-bio] medicine.anatomical_structure Insect Science Cell Division Research Article |
| Zdroj: | Journal of Virology Journal of Virology, 1991, 65 (7), pp.3928-3931 Journal of Virology, American Society for Microbiology, 1991, 65 (7), pp.3928-3931 Scopus-Elsevier Europe PubMed Central |
| ISSN: | 0022-538X 1098-5514 |
| Popis: | By using a series of deletion mutants, we have shown that the stimulation of fibroblast growth by E26 requires the cooperation of the two oncogenes, v-myb and v-ets, fused in the nuclear viral product. Of the two DNA-binding domains, only one must be present to promote anchorage-independent growth, whereas that of v-myb is required to allow growth in low serum medium. Furthermore, the v-ets oncogene comprises multifunctional domains. |
| Databáze: | OpenAIRE |
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