1D and 2D error assessment and correction for extrusion-based bioprinting using process sensing and control strategies
| Autor: | Andrew G. Alleyne, Ashley A. Armstrong, Amy J. Wagoner Johnson |
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| Rok vydání: | 2020 |
| Předmět: |
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Laser scanning Computer science 0206 medical engineering Biomedical Engineering Bioengineering Image processing 02 engineering and technology Biochemistry Displacement (vector) Biomaterials Process control Deposition (phase transition) business.industry Lasers Process (computing) Bioprinting General Medicine 021001 nanoscience & nanotechnology 020601 biomedical engineering Printing Three-Dimensional 0210 nano-technology business Quality assurance Computer hardware Biotechnology |
| Zdroj: | Biofabrication. 12(4) |
| ISSN: | 1758-5090 |
| Popis: | The bioprinting literature currently lacks: (i) process sensing tools to measure material deposition, (ii) performance metrics to evaluate system performance, and (iii) control tools to correct for and avoid material deposition errors. The lack of process sensing tools limits in vivo functionality of bioprinted parts since accurate material deposition is critical to mimicking the heterogeneous structures of native tissues. We present a process monitoring and control strategy for extrusion-based fabrication that addresses all three gaps to improve material deposition. Our strategy uses a non-contact laser displacement scanner that measures both the spatial material placement and width of the deposited material. We developed a custom image processing script that uses the laser scanner data and defined error metrics for assessing material deposition. To implement process control, the script uses the error metrics to modify control inputs for the next deposition iteration in order to correct for the errors. A key contribution is the definition of a novel method to quantitatively evaluate the accuracy of printed constructs. We implement the process monitoring and control strategy on an extrusion-printing system to evaluate system performance and demonstrate improvement in both material placement and material width. |
| Databáze: | OpenAIRE |
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