Hydronephrosis as a prognostic indicator of survival in advanced cervix cancer
| Autor: | Evangelia Katsoulakis, Tana S. Pradhan, Ovadia Abulafia, Ghadir Salame, Haiou Duan, Yi-Chun Lee |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Oncology
medicine.medical_specialty Urology Uterine Cervical Neoplasms Gynecologic oncology Hydronephrosis Adenocarcinoma Disease-Free Survival symbols.namesake Internal medicine medicine Humans Stage (cooking) Neoplasm Metastasis Cervix Fisher's exact test Neoplasm Staging Retrospective Studies Cervical cancer business.industry Obstetrics and Gynecology Cancer Middle Aged medicine.disease Prognosis Combined Modality Therapy Survival Analysis Confidence interval medicine.anatomical_structure Lymphatic Metastasis symbols Carcinoma Squamous Cell Female New York City business |
| Zdroj: | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 21(6) |
| ISSN: | 1525-1438 |
| Popis: | To determine whether hydronephrosis is an independent prognostic indicator of survival among patients with advanced cervical carcinoma. Moreover, we wanted to demonstrate the relationship between unilateral and bilateral hydronephrosis and overall survival.Retrospective analysis of 197 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIIB cervical carcinoma or higher treated between 1990 and 2007 was conducted. Inclusion criteria were clinical staging according to FIGO criteria, standardized radiation treatment and cisplatin-based chemosensitization regimens. Associations between hydronephrosis and covariates-age, race, histopathologic diagnosis, pelvic sidewall involvement, stage, nodal involvement, and Gynecologic Oncology Group/Eastern Cooperative Oncology Group performance status (PS)-were determined. Statistical analysis including Kaplan-Meier, log-rank test, proportional hazards regression, Fisher exact test, and Mann-Whitney test were used where appropriate, with P0.05 considered significant.Of 143 included patients, 73 patients had no hydronephrosis (HN), 39 patients had unilateral HN, and 31 patients had bilateral HN. Twenty-nine patients (40%) with no HN died compared to 24 patients (61.5%) with unilateral HN and 21 patients (67.7%) with bilateral HN. Median time to death was significantly shorter for patients with unilateral HN (27 months; 95% confidence interval [CI], 10-48) and bilateral HN (12 months; 95% CI, 6-23) versus patients without HN (68 months; 95% CI, 39-∞; P0.001). Unadjusted hazard ratio (HR) for HN (both unilateral and bilateral) was 2.4 (95% CI, 1.5-3.8); P0.001. Of potential covariates evaluated, PS and sidewall involvement were significantly associated with HN (P = 0.021 and P = 0.014, respectively). Proportional hazards regression revealed that controlling for use of radiation, chemotherapy, and for PS, HN was still significantly associated with poor prognosis (HR unilateral HN = 2.0, 95% CI, 1.2-3.5; HR bilateral HN = 3.2, 95% CI, 1.7-6.0); P ≤ 0.001.Hydronephrosis is an independent poor prognostic indicator of survival in patients with advanced cervical cancer. Bilateral hydronephrosis compared to unilateral involvement confers a worse overall prognosis. Additional studies are needed to determine if FIGO staging should be amended. |
| Databáze: | OpenAIRE |
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