Seroprevalence for norovirus genogroups GII and GIV in captive non-human primates
| Autor: | Vito Martella, Fulvio Marsilio, Federico Coccia, Ivano Massirio, Sandra Bermudez Sanchez, Federica Di Profio, Andrea Palombieri, Vittorio Sarchese, Irene Melegari, Klaus Gunther Friedrich, Barbara Di Martino |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Epidemiology Immunology and Microbiology (all) 030106 microbiology 030231 tropical medicine Biology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine stomatognathic system Seroepidemiologic Studies Genotype medicine Animals Seroprevalence Mangabey genotypes GII.4 and GIV.1 IgG antibodies non-human primates noroviruses Veterinary (all) Public Health Environmental and Occupational Health Infectious Diseases General Veterinary General Immunology and Microbiology Transmission (medicine) Monkey Diseases Epidemic gastroenteritis Environmental and Occupational Health Hominidae Haplorhini Serum samples Virology Ape Diseases Italy Norovirus biology.protein Animals Zoo Public Health Antibody |
| Popis: | Noroviruses (NoVs) are a major cause of epidemic gastroenteritis in children and adults. Several pieces of evidence suggest that viruses genetically and antigenically closely related to human NoVs might infect animals, raising public health concerns about potential cross-species transmission. The natural susceptibility of non-human primates (NPHs) to human NoV infections has already been reported, but a limited amount of data is currently available. In order to start filling this gap, we screened a total of 86 serum samples of seven different species of NPHs housed at the Zoological Garden (Bioparco) of Rome (Italy), collected between 2001 and 2017, using an enzyme-linked immunosorbent assay (ELISA) based on virus-like particles (VLPs) of human GII.4 and GIV.1 NoVs. Antibodies specific for both genotypes were detected with an overall prevalence of 32.6%. In detail, IgG antibodies against GII.4 NoVs were found in 18 Japanese macaques (29.0%, 18/62), a mandrill (10.0%, 1/10), a white-crowned mangabey (16.6%, 1/6) and in an orangutan (33.3%, 1/3). Twelve macaques (19.3%, 12/62), five mandrills (50.0%, 5/10), two chimpanzees (100%, 2/2) and a white-crowned mangabey (16.6%, 1/6) showed antibodies for GIV.1 NoVs. The findings of this study confirm the natural susceptibility of captive NHPs to GII NoV infections. In addition, IgG antibodies against GIV.1 were detected, suggesting that NHPs are exposed to GIV NoVs or to antigenically related NoV strains. |
| Databáze: | OpenAIRE |
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