Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu
| Autor: | Wen-Jie Zhou, Da-Jin Li, Xin-Xin Hou, Xiao-Qiu Wang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
QH301-705.5 THP-1 Cells Endometriosis Macrophage polarization T cells Medicine (miscellaneous) T-Lymphocytes Regulatory General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences 0302 clinical medicine medicine Metallothionein Humans Biology (General) Receptor Chemistry Peritoneal fluid Macrophages Fibrinogen U937 Cells Chronic inflammation medicine.disease Phenotype FGL2 Cell biology 030104 developmental biology Cytokines Female Signal transduction General Agricultural and Biological Sciences 030215 immunology |
| Zdroj: | Communications Biology Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021) |
| ISSN: | 2399-3642 |
| Popis: | An increased number of highly active regulatory T cells (Tregs) and macrophages has been found in peritoneal fluid from women with endometriosis. Here, we show that the level of Tregs-derived soluble fibrinogen-like protein 2 (sFGL2) increases in the peritoneal fluid of women with endometriosis. Higher expression of FGL2 and its receptor CD32B is observed in eutopic endometrium and ectopic tissues. The production of sFGL2 in Tregs may be enhanced by several cytokines. sFGL2 selectively induces pro-repair macrophage polarization mainly through the activation of the SHP2-ERK1/2-STAT3 signaling pathway, and the suppression of the NF-κB signaling pathway. Furthermore, sFGL2 induces a much higher level of metallothionein (MT) expression that in turn facilitates pro-repair macrophages polarization. sFGL2-induced pro-repair macrophages promote Th2 and Tregs differentiation, creating a positive feedback loop. These findings suggest that sFGL2 secreted by Tregs skews macrophages toward a pro-repair phenotype via SHP2-ERK1/2-STAT3 signaling pathway, which is involved in the progression of endometriosis. Hou et al. discover that regulatory T-cells secrete soluble fibrinogen-like protein 2 that induces endometrial macrophages to polarize towards a pro-repair phenotype through the SHP2-ERK1/2-STAT3 signaling pathway. These data provide insights into the immunology of endometriosis. |
| Databáze: | OpenAIRE |
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