Thermography basket catheter: In vivo measurement of the temperature of atherosclerotic plaques for detection of vulnerable plaques
| Autor: | Mohammad Madjid, Khawar Gul, Silvio H. Litovsky, Morteza Naghavi, S. Ward Casscells, James T. Willerson, Mir Said Siadaty |
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| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty Hot Temperature Coronary Artery Disease Femoral artery medicine.disease_cause Dogs Predictive Value of Tests In vivo medicine.artery medicine Animals Radiology Nuclear Medicine and imaging Inflammation Aorta business.industry General Medicine Vulnerable plaque Disease Models Animal Catheter Thermography Data acquisition software Rabbits Cardiology and Cardiovascular Medicine business Basket catheter Nuclear medicine |
| Zdroj: | Catheterization and Cardiovascular Interventions. 59:52-59 |
| ISSN: | 1522-726X 1522-1946 |
| DOI: | 10.1002/ccd.10486 |
| Popis: | We have developed an intravascular thermography basket catheter to measure the temperature of the vessel wall to locate foci of inflammation. Our 3 Fr thermography basket catheter is a thermocouple-based catheter made of a nitinol expandable and externally controllable basket system loaded with nine small and flexible built-in thermosensors. It is equipped with real-time data acquisition software with a thermal resolution of 0.0001°C and a sampling rate of 20 readings per second. In 10 inbred cholesterol-fed dogs with femoral (but not carotid) atherosclerosis, we found foci of warmth on the surface of atherosclerotic but not disease-free regions (P < 0.05). Marked temperature heterogeneity was also observed in the aortas of atherosclerotic Watanabe rabbits but not in normal rabbits. The catheters showed satisfactory accuracy, reproducibility, and safety. If confirmed in further studies, it has the potential to be utilized in detection of vulnerable plaques. Cathet Cardiovasc Intervent 2003;59:52–59. © 2003 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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