Impact of chemotherapy for breast cancer on leukocyte DNA methylation landscape and cognitive function: a prospective study
| Autor: | Li Yan, Kelley Lynn Young, Michelle C. Janelsins, Song Yao, Javier Bautista, Sarah L. Kerns, Adedayo A. Onitilo, Jamal Misleh, Supriya G. Mohile, Lianlian Lei, Christine B. Ambrosone, Song Liu, Qiang Hu, Mostafa R. Mohamed |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty lcsh:QH426-470 medicine.medical_treatment lcsh:Medicine Antineoplastic Agents Breast Neoplasms Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Breast cancer Cognition Internal medicine Genetics medicine Leukocytes Humans Chemotherapy Epigenetics Prospective Studies Cognitive decline Molecular Biology Genetics (clinical) Neoplasm Staging DNA methylation business.industry Research lcsh:R Cancer Methylation medicine.disease Chemotherapy regimen 3. Good health lcsh:Genetics 030104 developmental biology Treatment Outcome 030220 oncology & carcinogenesis CpG Islands Female Cognitive function business Developmental Biology |
| Zdroj: | Clinical Epigenetics Clinical Epigenetics, Vol 11, Iss 1, Pp 1-10 (2019) |
| ISSN: | 1868-7083 |
| Popis: | Background Little is known about the effects of chemotherapeutic drugs on DNA methylation status of leukocytes, which may be predictive of treatment benefits and toxicities. Based on a prospective national study, we characterize the changes in leukocyte DNA methylome from pre- to post-chemotherapy (approximately 4 months apart) in 93 patients treated for early stage breast cancer and 48 matched non-cancer controls. We further examined significant methylation changes with perceived cognitive impairment, a clinically significant problem related to cancer and chemotherapy. Results Approximately 4.2% of the CpG sites measured using the Illumina 450K methylation array underwent significant changes after chemotherapy (p |
| Databáze: | OpenAIRE |
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