A dual-site controlled pH probe revealing the pH of sperm cytoplasm and screening for healthy spermatozoa

Autor: Xiaoliang Li, Kun Li, Xiao-Qi Yu, Kang-Kang Yu, Sixian Wu, Xiaohui Jiang, Zhiwen Chu, Jianwen Hou, Wenming Xu, Chuan Jiang
Rok vydání: 2021
Předmět:
Zdroj: Journal of Materials Chemistry B. 9:3662-3665
ISSN: 2050-7518
2050-750X
DOI: 10.1039/d1tb00108f
Popis: A dual-site controlled pH probe, which is composed of gold nanoparticles and modified with rhodamine and fluorescein derivatives, was applied to sensitively monitor intracellular pH changes in sperm. The pH probe revealed the intracellular pH of sperm under different conditions and demonstrated the lower pH in asthenozoospermia patients as compared to healthy individuals. Importantly, the pH probe can help screen for healthy sperm.
Databáze: OpenAIRE