Cytotoxic steroidal saponins from the rhizomes of Paris fargesii var. Petiolata

Autor: Yun-Yuan Tian, Yang Liu, Peng-Cheng Qiu, Yao Li, Jin-Ming Hu, Tian-Yi Li, Wen-Wen Chen, Hai-Feng Tang, Yun-Yang Lu
Rok vydání: 2023
Předmět:
Zdroj: Bioorganic Chemistry. 131:106305
ISSN: 0045-2068
DOI: 10.1016/j.bioorg.2022.106305
Popis: Phytochemical investigation on the rhizomes of Paris fargesii var. petiolata (Baker ex C. H. Wright) Wang et Tang led to the isolation of five previously undescribed steroidal saponins, parpetiosides A-E (1-5), and six known analogs (6-11). Their structures were established by extensive spectroscopic data analysis and chemical methods. Compound 5 was a rare steroidal saponin with disaccharide moiety linked at C-26 of dehydrokryptogenin that was hardly seen in the genus Paris. The cytotoxicities of the isolated compounds against three human cancer cell lines (U87, HepG2 and SGC-7901) were evaluated, and compound 1 displayed certain inhibitory effect with IC
Databáze: OpenAIRE