Simultaneous Assessment of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor in Epithelial Lining Fluid From Patients With COPD
| Autor: | Kazuhisa Asai, Kazuto Hirata, Yoshihiro Tochino, Hiroshi Kanazawa |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Pulmonary and Respiratory Medicine medicine.medical_specialty Pathology Biopsy Bronchi Enzyme-Linked Immunosorbent Assay Critical Care and Intensive Care Medicine Severity of Illness Index Gastroenterology Epithelium Pulmonary function testing Pathogenesis Pulmonary Disease Chronic Obstructive chemistry.chemical_compound Diffusing capacity Internal medicine Bronchoscopy medicine Humans Aged COPD Lung Hepatocyte Growth Factor business.industry Middle Aged Prognosis medicine.disease respiratory tract diseases Vascular endothelial growth factor Vascular endothelial growth factor A medicine.anatomical_structure chemistry behavior and behavior mechanisms Pulmonary Diffusing Capacity Female Hepatocyte growth factor Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business Biomarkers Follow-Up Studies medicine.drug |
| Zdroj: | Chest. 146:1159-1165 |
| ISSN: | 0012-3692 |
| Popis: | BACKGROUND Hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) are involved in the pathogenesis of various lung diseases. This study was designed to determine the possible interactions of these growth factors in the development of COPD. METHODS We measured the levels of HGF and VEGF in epithelial lining fluid obtained from central or peripheral airways using a bronchoscopic microsampling technique in 10 never smokers, 14 smokers without COPD, and 24 smokers with COPD. We also evaluated whether their levels were correlated with pulmonary function parameters and the grade of low attenuation area (LAA) observed in high-resolution CT scans. RESULTS HGF and VEGF levels in the peripheral airways of smokers with COPD were significantly lower than those in never smokers and smokers without COPD. In smokers with COPD, HGF and VEGF levels of the peripheral airways inversely correlated with the degree of airway obstruction and diffusing capacity of the lung. The HGF and VEGF levels also correlated with the grade of LAA. Although the VEGF levels of smokers with and without COPD overlapped considerably, HGF levels were markedly higher in smokers without COPD. CONCLUSIONS Upregulated HGF probably compensated for the reduced levels of VEGF and preserved the pulmonary function in smokers without COPD. By contrast, both HGF and VEGF levels were decreased in smokers with COPD, which likely led to the development of COPD. Thus, the level of HGF relative to that of VEGF may be a reliable indicator of the risk for COPD. |
| Databáze: | OpenAIRE |
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