Right-sided heart failure is also associated with transverse tubule remodeling in the left ventricle
| Autor: | June-Chiew Han, Denis S. Loiselle, J.M. Ross, Kevin Howe, David J. Crossman |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Sarcomeres medicine.medical_specialty Physiology Heart Ventricles Ventricular Function Left Physiology (medical) Internal medicine medicine Animals Calcium Signaling Rats Wistar Heart Failure Monocrotaline Hypertrophy Right Ventricular Ventricular Remodeling business.industry Membrane Proteins Ryanodine Receptor Calcium Release Channel musculoskeletal system medicine.disease Transverse tubule Disease Models Animal medicine.anatomical_structure Ventricle Heart failure Ventricular Function Right Cardiology Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business Right-sided heart failure |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 321:H940-H947 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.00298.2021 |
| Popis: | In this work, we demonstrate that t-tubule remodeling occurs in the atrophied left ventricle as well as the overloaded right ventricle after right-side heart failure. Moreover, we identify that t-tubule remodeling in both ventricles is linked to sarcoplasmic reticulum remodeling as indicated by decreased labeling periodicity of both the Ca2+ release channel, RyR2, and the cardiac junction-forming protein, JPH2, that forms a link between the sarcoplasmic reticulum and sarcolemma. Studies developing treatments for right-sided heart failure should consider effects on both the right and left ventricle. |
| Databáze: | OpenAIRE |
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