Deep brain stimulation of the pedunculopontine tegmentum and subthalamic nucleus: effects on gait in Parkinson's disease
| Autor: | M. Musicco, Mariangela Pierantozzi, Fabio Marchetti, Antonella Peppe, Alessandro Stefani, Paolo Stanzione, C. Chiavalon, Carlo Caltagirone |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Range of Motion
STN Male medicine.medical_specialty Deep brain stimulation Parkinson's disease Knee Joint medicine.medical_treatment Deep Brain Stimulation Biophysics DBS behavioral disciplines and activities Antiparkinson Agents Gait (human) Subthalamic Nucleus medicine Pedunculopontine Tegmental Nucleus Humans Orthopedics and Sports Medicine Biomechanics Range of Motion Articular Gait Pedunculopontine tegmentum business.industry Rehabilitation Hip Joint Parkinson Disease PPTg medicine.disease nervous system diseases Biomechanical Phenomena Subthalamic nucleus surgical procedures operative Neuronal circuits nervous system Gait analysis Settore MED/26 - Neurologia Neurosurgery business Neuroscience therapeutics Articular |
| Zdroj: | Gait & posture 32 (2010): 512–518. doi:10.1016/j.gaitpost.2010.07.012 info:cnr-pdr/source/autori:Peppe A, Pierantozzi M, Chiavalon C, Marchetti F, Caltagirone C, Musicco M, Stanzione P, Stefani A./titolo:Deep brain stimulation of the pedunculopontine tegmentum and subthalamic nucleus Effects on gait in Parkinson's disease/doi:10.1016%2Fj.gaitpost.2010.07.012/rivista:Gait & posture/anno:2010/pagina_da:512/pagina_a:518/intervallo_pagine:512–518/volume:32 |
| ISSN: | 1879-2219 |
| DOI: | 10.1016/j.gaitpost.2010.07.012 |
| Popis: | Objective This study examines the effects of subthalamic nucleus (STN) deep brain stimulation (DBS) and pedunculopontine tegmentum (PPTg) DBS in advanced Parkinson's disease using gait analysis. Methods Five people underwent bilateral DBS in both the STN and PPTg. Gait analysis was performed one year after neurosurgery using an optoelectronic system. The effects of DBS (STN, PPTg and STN + PPTg) were studied in two clinical conditions: without (Off) and during (On) antiparkinsonian therapy. Results PPTg and STN DBS were associated with changes in spatio-temporal and kinematics variables. Conclusions Although experimental data cannot be generalized widely due to the small sample, PPTg DBS appears to affect the neuronal circuits subserving gait. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect