Opioids modulate constitutive B-lymphocyte secretion
| Autor: | Efstathia Bakogeorgou, Elias Castanas, Helen Dimitriou, Marilena Kampa, Anastassia Hatzoglou, Despoina Vassou |
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| Přispěvatelé: | Laboratory of Experimental Endocrinology, University of Crete [Heraklion] (UOC), Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération (LBCMCP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
MESH: Signal Transduction
MESH: Immunoglobulins Ethylketocyclazocine Lymphocyte medicine.medical_treatment Receptors Opioid mu MESH: Multiple Myeloma MESH: Analgesics Opioid p38 Mitogen-Activated Protein Kinases MESH: Dose-Response Relationship Drug MESH: Ethylketocyclazocine 0302 clinical medicine Opioid receptor MESH: Reverse Transcriptase Polymerase Chain Reaction Immunology and Allergy Phosphorylation MESH: Peptide Fragments B-Lymphocytes 0303 health sciences MESH: Cytokines MESH: Antigens CD19 Reverse Transcriptase Polymerase Chain Reaction Caseins Analgesics Opioid medicine.anatomical_structure Cytokine Cytokines Multiple Myeloma Signal Transduction medicine.drug MESH: Interleukins MESH: Receptors Opioid kappa medicine.drug_class Antigens CD19 Immunology Immunoglobulins MESH: Receptors Opioid mu [SDV.BC]Life Sciences [q-bio]/Cellular Biology In Vitro Techniques Biology MESH: Caseins Cell Line 03 medical and health sciences Immune system MESH: B-Lymphocytes medicine Humans Secretion 030304 developmental biology Pharmacology MESH: Humans Dose-Response Relationship Drug MESH: Phosphorylation Interleukins Receptors Opioid kappa Peptide Fragments MESH: Cell Line MESH: p38 Mitogen-Activated Protein Kinases Opioid Cytokine secretion 030217 neurology & neurosurgery |
| Zdroj: | International Immunopharmacology International Immunopharmacology, Elsevier, 2008, 8 (5), pp.634-44. ⟨10.1016/j.intimp.2008.01.002⟩ |
| ISSN: | 1567-5769 |
| Popis: | The opioid system plays a major role in immunomodulation, while its action on cells of the immune system may be opioid receptor-mediated or not. Opioid effects on B-lymphocytes are considered as indirect, attributed to an interplay between distinct cell populations. The aim of the present study was to investigate whether opioid agonists (morphine, alpha S1 -casomorphin and ethylketocyclazocine) may have a direct action on the secretion of antibodies and cytokines by multiple myeloma-derived cell lines and normal CD19 + B-lymphocytes. Our results show that opioids modulate antibody and cytokine secretion by multiple myeloma cells in a cell line-dependent and opioid receptor-independent manner, while they decrease antibody secretion by normal B-lymphocytes. Furthermore, they decrease the proliferation rate of multiple myeloma cells through opioid receptor activation. Our data suggest two different mechanisms of action of opioids, mediated by different signaling pathways: an early non-opioid receptor-related effect, modulating the constitutive immunoglobulin and cytokine secretion, and a long-term receptor-mediated action on cell growth. These data suggest a further opioid implication in the control of humoral immunity. |
| Databáze: | OpenAIRE |
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