Benzylamidine complexes of platinum(II) derived by nucleophilic addition of primary and secondary amines. X-ray crystal structure of trans-[PtCl2{Z-N(H)C(NHMe)CH2Ph}2]

Autor: Roberta Bertani, Rino A. Michelin, Silvia Mazzega Sbovata, Christine Marzano, Mirto Mozzon, Frazia Bettio, Franco Benetollo
Rok vydání: 2008
Předmět:
Zdroj: Inorganica Chimica Acta (Testo stamp.) 361 (2008): 3109–3116.
info:cnr-pdr/source/autori:Mazzega Sbovata S. 1, Bettio Frazia 2, Marzano Christine 2, Mozzon Mirto 1, Bertani Roberta 1, Benetollo Franco 3, Michelin Rino A. 1/titolo:Benzylamidine complexes of platinum(II) derived by nucleophilic addition of primary and secondary amines. X-ray crystal structure of trans-[PtCl2{Z-N(H)=C(NHMe)CH2Ph}2]/doi:/rivista:Inorganica Chimica Acta (Testo stamp.)/anno:2008/pagina_da:3109/pagina_a:3116/intervallo_pagine:3109–3116/volume:361
ISSN: 0020-1693
DOI: 10.1016/j.ica.2007.10.054
Popis: The reaction of cis - and trans -[PtCl 2 (NCCH 2 Ph) 2 ] with a 5-fold excess of MeNH 2 and Me 2 NH in CH 2 Cl 2 at −10 °C affords in high yield the bis-amidine derivatives cis - and trans -[PtCl 2 { Z -N(H) C(NHMe)CH 2 Ph} 2 ] ( 1a , 2a ) and cis - and trans -[PtCl 2 { E -N(H) C(NMe 2 )CH 2 Ph} 2 ] ( 3a , 4a ), respectively. The complexes were characterized by means of elemental analysis, multinuclear NMR and FT-IR techniques. The X-ray diffraction analysis was carried out for trans -[PtCl 2 { Z -N(H) C(NHMe)CH 2 Ph} 2 ] ( 2a ). Moreover, the in vitro cytotoxicity for the new derivatives was evaluated in a wide panel of human tumor cell lines.
Databáze: OpenAIRE
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