CD-Search: protein domain annotations on the fly
| Autor: | Aron Marchler-Bauer, Stephen H. Bryant |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Internet
Time Factors Information retrieval Multiple sequence alignment Architecture domain Conserved Domain Database Simple Modular Architecture Research Tool Structural alignment Protein domain Proteins Articles Domain model Biology Bioinformatics Protein Structure Tertiary User-Computer Interface Sequence logo Sequence Analysis Protein Consensus Sequence Computer Graphics Genetics Amino Acid Sequence Sequence Alignment Software |
| Zdroj: | Nucleic Acids Research. 32:W327-W331 |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | We describe the Conserved Domain Search service (CD-Search), a web-based tool for the detection of structural and functional domains in protein sequences. CD-Search uses BLAST(R) heuristics to provide a fast, interactive service, and searches a comprehensive collection of domain models. Search results are displayed as domain architecture cartoons and pairwise alignments between the query and domain-model consensus sequences. Search results may be visualized in further detail by embedding the query sequence into multiple alignment displays and by mapping onto three-dimensional molecular graphic displays of known structures within the domain family. CD-Search can be accessed at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi. |
| Databáze: | OpenAIRE |
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