Chemical biology probes of mammalian GLUT structure and function
| Autor: | Holman, Geoffrey D. |
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| Rok vydání: | 2018 |
| Předmět: |
Models
Molecular 0301 basic medicine Research groups medicine.medical_treatment Cell Glucose Transport Proteins Facilitative Chemical biology Review Article Biology Biochemistry 03 medical and health sciences 0302 clinical medicine Protein Domains medicine Animals Humans Obesity insulin action Review Articles Molecular Biology Mammals Insulin Glucose transporter Cell Biology Membrane transport GLUT proteins Structure and function Cell biology Glucose 030104 developmental biology medicine.anatomical_structure Cell metabolism Diabetes Mellitus Type 2 GLUT4 translocation 030217 neurology & neurosurgery Protein Binding |
| Zdroj: | Biochemical Journal |
| ISSN: | 1470-8728 0264-6021 |
| DOI: | 10.1042/bcj20170677 |
| Popis: | The structure and function of glucose transporters of the mammalian GLUT family of proteins has been studied over many decades, and the proteins have fascinated numerous research groups over this time. This interest is related to the importance of the GLUTs as archetypical membrane transport facilitators, as key limiters of the supply of glucose to cell metabolism, as targets of cell insulin and exercise signalling and of regulated membrane traffic, and as potential drug targets to combat cancer and metabolic diseases such as type 2 diabetes and obesity. This review focusses on the use of chemical biology approaches and sugar analogue probes to study these important proteins. |
| Databáze: | OpenAIRE |
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