Deciphering the Identity of Renin Cells in Health and Disease
| Autor: | Alexandre de Goes Martini, Omar Guessoum, R. Ariel Gomez, Maria Luisa S. Sequeira-Lopez |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Myocytes Smooth Muscle Stimulation Context (language use) Kidney Article Renin-Angiotensin System 03 medical and health sciences 0302 clinical medicine Immune system Internal medicine Renin Renin–angiotensin system medicine Animals Humans Secretion Molecular Biology business.industry Transdifferentiation Nephrons Water-Electrolyte Balance 030104 developmental biology medicine.anatomical_structure Endocrinology Hepatocytes Blood Vessels Molecular Medicine Hypotension business 030217 neurology & neurosurgery Homeostasis |
| Zdroj: | Trends Mol Med |
| ISSN: | 1471-4914 |
| Popis: | Hypotension and changes in fluid-electrolyte balance pose immediate threats to survival. Juxtaglomerular cells respond to such threats by increasing the synthesis and secretion of renin. In addition, smooth muscle cells (SMCs) along the renal arterioles transform into renin cells until homeostasis has been regained. However, chronic unrelenting stimulation of renin cells leads to severe kidney damage. Here, we discuss the origin, distribution, function, and plasticity of renin cells within the kidney and immune compartments and the consequences of distorting the renin program. Understanding how chronic stimulation of these cells in the context of hypertension may lead to vascular pathology will serve as a foundation for targeted molecular therapies. |
| Databáze: | OpenAIRE |
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