Mechanisms of nanotoxicity – biomolecule coronas protect pathological fungi against nanoparticle-based eradication
| Autor: | Sven Becker, Eckhard Thines, Madita Wandrey, Dana Westmeier, Shirley K. Knauer, Roland H. Stauber, Dominic Docter, Svenja Siemer, Guo-Bin Ding |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Antifungal Agents
Surface Properties Biomedical Engineering Medizin Nanoparticle Nanotechnology 02 engineering and technology 010501 environmental sciences Toxicology Models Biological 01 natural sciences Drug Resistance Fungal Animals Humans Ecosystem 0105 earth and related environmental sciences chemistry.chemical_classification Microbial Viability Biomolecule Spores Fungal Silicon Dioxide 021001 nanoscience & nanotechnology chemistry Nanotoxicology Nanoparticles Nanomedicine Adsorption Botrytis 0210 nano-technology Biologie |
| Popis: | Whereas nanotoxicity is intensely studied in mammalian systems, our knowledge of desired or unwanted nano-based effects for microbes is still limited. Fungal infections are global socio-economic health and agricultural problems, and current chemical antifungals may induce adverse side-effects in humans and ecosystems. Thus, nanoparticles are discussed as potential novel and sustainable antifungals via the desired nanotoxicity but often fail in practical applications. In our study, we found that nanoparticles' toxicity strongly depends on their binding to fungal spores, including the clinically relevant pathogen |
| Databáze: | OpenAIRE |
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