Homotypic and Heterotypic Protection and Risk of Reinfection Following Natural Norovirus Infection in a Highly Endemic Setting
| Autor: | Lawrence H. Moulton, Preeti Chhabra, Mery Siguas Salas, Maribel Paredes Olortegui, Pablo Peñataro Yori, Saba Rouhani, Hannah Browne, Jan Vinjé, Margaret Kosek |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) viruses 030106 microbiology medicine.disease_cause law.invention Cohort Studies 03 medical and health sciences fluids and secretions law homotypic protection Genotype Humans Medicine Genotyping Polymerase chain reaction Caliciviridae Infections business.industry Proportional hazards model Norovirus Hazard ratio virus diseases Acute gastroenteritis Gastroenteritis Major Articles and Commentaries AcademicSubjects/MED00290 030104 developmental biology Infectious Diseases Reinfection heterotypic protection Immunology GII.4 business Re infection |
| Zdroj: | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/cid/ciaa019 |
| Popis: | Background Norovirus is a leading cause of acute gastroenteritis worldwide, yet there is limited information on homotypic or heterotypic protection following natural infection to guide vaccine development. Methods A total of 6020 stools collected from 299 Peruvian children between 2010 and 2014 were tested by norovirus real-time reverse-transcription polymerase chain reaction followed by sequence-based genotyping. Cox proportional hazards models were used to derive adjusted hazard ratios (HRs) of infection among children with vs without prior exposure. Results Norovirus was detected in 1288 (21.3%) samples. GII.4 (26%), GII.6 (19%), and GI.3 (9%) viruses accounted for 54% of infections. Homotypic protection for GI.3 (HR, 0.35; P = .015), GI.7 (HR, 0.19; P = .022), GII.4 (HR, 0.39; P Infections with GII.4 noroviruses demonstrated both homotypic and heterotypic protection. However, increased hazard of subsequent infection following infection with several other common genotypes will require additional studies prior to the inclusion of additional genotypes in a multivalent vaccine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|