Role of fluoxetine in pharmacological enhancement of motor functions in stroke patients: A randomized, placebo-controlled, single-blind trial

Autor: Neethu Sara Raju, Yalamanchili Dharma Teja, Vikrama Simha Reddy, Kiran Kumar Rathinam, Karthickeyan Krishnan, Muthuraj K, Nandhini K
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Contemporary Clinical Trials Communications, Vol 23, Iss, Pp 100800-(2021)
Contemporary Clinical Trials Communications
ISSN: 2451-8654
Popis: Background Stroke is the primary cause of disability worldwide, the second most common cause of dementia and the third leading cause of death. Only few studies were conducted to study the role of fluoxetine in motor recovery in either ischemic or hemorrhagic stroke patients with probably less severe paresis. However, the current study evaluates both the effectiveness and safety of fluoxetine in the stroke population with a more severe motor deficit. Methods Patients who had acute or subacute stroke with hemiparesis and aged between 18 and 80 years with medical research council (MRC) scale score
Highlights • According to American stroke association – 2/3 of stroke survivors continue to live with one or more disabilities. • Fluoxetine, a selective serotonin reuptake inhibitor have neurotrophic and neuroprotective action. • Early administration of Fluoxetine is effective in stroke rehabilitation by enhancing motor function.
Databáze: OpenAIRE