Neural signatures of loss of consciousness and its recovery by thalamic stimulation
| Autor: | Emery N. Brown, Earl K. Miller, Jorge Yanar, Meredith Mahnke, André M. Bastos, Jacob A. Donoghue, Simon Kornblith |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
business.industry media_common.quotation_subject Unconsciousness Thalamus Stimulation Local field potential 03 medical and health sciences 0302 clinical medicine medicine medicine.symptom Consciousness Propofol business Thalamic stimulator Neuroscience 030217 neurology & neurosurgery Cortical rhythms 030304 developmental biology medicine.drug media_common |
| DOI: | 10.1101/806687 |
| Popis: | We know that general anesthesia produces unconsciousness but not quite how. We recorded neural activity from the frontal, parietal, and temporal cortices and thalamus while maintaining unconsciousness in non-human primates (NHPs) with propofol. Unconsciousness was marked by slow frequency (∼1 Hz) oscillations in local field potentials, entraining local spiking to Up states alternating with Down states of little spiking, and decreased higher frequency (>4 Hz) coherence. The thalamus contributed to cortical rhythms. Its stimulation “awakened” anesthetized NHPs and reversed the electrophysiologic features of unconsciousness. Unconsciousness thus resulted from slow frequency hypersynchrony and loss of high-frequency dynamics, partly mediated by the thalamus, that disrupts cortical communication/integration. |
| Databáze: | OpenAIRE |
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