CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival
| Autor: | Evelyna Derhovanessian, Karin Hähnel, Andrea B. Maier, Graham Pawelec, Helene Roelofs, Anton J. M. de Craen, Rudi G. J. Westendorp, Sai-Juan Chen |
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| Přispěvatelé: | Neuromechanics, Research Institute MOVE, Internal medicine, MOVE Research Institute |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
T-Lymphocytes
Regulatory/physiology Adult Aging Receptors CCR4 Adolescent T-Lymphocytes Population CCR4 Cytomegalovirus Tregs Inflammation chemical and pharmacologic phenomena T-Lymphocytes Regulatory Chemokine receptor C-Reactive Protein/analysis Elderly Immune system SDG 3 - Good Health and Well-being CCR4/analysis Receptors medicine 80 and over Humans Mortality education Survival rate Receptors CCR4/analysis Aged Aging/immunology Aged 80 and over education.field_of_study business.industry Peripheral tolerance hemic and immune systems Immunosenescence Middle Aged Cytomegalovirus Infections/immunology C-Reactive Protein Regulatory/physiology Cytomegalovirus Infections Immunology Geriatrics and Gerontology medicine.symptom business |
| Zdroj: | The journals of gerontology. Series A : Biological sciences and medical sciences, 70(8), 917-23. Oxford University Press Journal of Gerontology: Medical Sciences, 70(8), 917-923 Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, 70(8), 917-923. Oxford University Press Derhovanessian, E, Chen, S, Maier, A B, Hähnel, K, de Craen, A J M, Roelofs, H, Westendorp, R & Pawelec, G 2015, ' CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival ', The journals of gerontology. Series A : Biological sciences and medical sciences, vol. 70, no. 8, pp. 917-23 . https://doi.org/10.1093/gerona/glu128 Derhovanessian, E, Chen, S, Maier, A B, Hahnel, K, Craen, A J M, Roelofs, H, Westendorp, R & Pawelec, G 2015, ' CCR4(+) Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival ', Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, vol. 70, no. 8, pp. 917-923 . https://doi.org/10.1093/gerona/glu128 |
| ISSN: | 1079-5006 |
| DOI: | 10.1093/gerona/glu128 |
| Popis: | CD4(+) regulatory T cells (Tregs) are a distinct population of T cells involved in maintaining peripheral tolerance to self-antigens. Several studies have shown increased frequency and number of Tregs in the elderly. Whether such an increase has any clinical relevance has not been addressed. Here, we have analyzed circulating Tregs in 114 donors between the ages of 18 and 89 years and assessed their implications for survival of the very elderly. In line with previously published data, we observed higher proportions of Tregs in the elderly. Expression of chemokine receptor 4 (CCR4) by Tregs has been shown to characterize antigen-primed activated Tregs with immediate suppressive function. Thus we further analyzed Tregs expressing or lacking this chemokine receptor. There were more CCR4(+) and CCR4(-) Tregs in the elderly than the young. Finally, using a subset of 48 elderly donors participating in the Leiden 85-plus study we documented that people with greater median frequencies of CCR4(+) Tregs enjoyed a better 8-year survival rate than those with lower frequencies of these cells. Our data, demonstrating for the first time a positive correlation between increased frequency of Tregs and survival in the elderly, imply an increasing importance of controlling inappropriate immune responses and inflammation as we grew old. |
| Databáze: | OpenAIRE |
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