The impact of new-onset cancer among veterans who are receiving warfarin for atrial fibrillation and venous thromboembolism
Autor: | Adam J. Rose, Joel I. Reisman, Daniel B. Ambrus |
---|---|
Rok vydání: | 2016 |
Předmět: |
Male
medicine.medical_specialty Warfarin therapy Hemorrhage Newly diagnosed 030204 cardiovascular system & hematology New onset Cohort Studies 03 medical and health sciences 0302 clinical medicine Neoplasms Internal medicine Atrial Fibrillation medicine Humans cardiovascular diseases 030212 general & internal medicine Aged Veterans Aged 80 and over business.industry Warfarin Anticoagulants Atrial fibrillation Venous Thromboembolism Hematology Middle Aged medicine.disease Treatment Outcome Cardiology Female business Venous thromboembolism Major bleeding medicine.drug Cohort study |
Zdroj: | Thrombosis Research. 144:21-26 |
ISSN: | 0049-3848 |
DOI: | 10.1016/j.thromres.2016.05.028 |
Popis: | Background A new cancer diagnosis adds significant complexity and uncertainty to the management of pre-existing warfarin therapy. Objectives To determine how new-onset cancer affects anticoagulation control and outcomes among patients who had been receiving warfarin for atrial fibrillation (AF) compared to patients who had been receiving warfarin for venous thromboembolism (VTE) prior to cancer diagnosis. Patients/methods This cohort study started with 122,875 veterans who had been receiving warfarin for at least six months from a VA Medical Center between 10/1/06 and 9/30/08. We identified patients with incident cancer during this interval, and excluded those with a prior cancer history. We analyzed percent time in therapeutic range (TTR) at 6 and 12-month intervals after cancer diagnosis compared to pre-cancer baseline, as well as crude rates of warfarin-relevant outcomes (stroke, major bleeding, mortality) between patients with AF and VTE. Results Among patients with new-onset cancer, patients anticoagulated for AF outnumbered those anticoagulated for VTE more than 2.5-fold. There were no significant differences in TTR by indication for warfarin in months 0–6 or 7–12 following cancer diagnosis, but TTR decreased significantly compared to the pre-cancer baseline for both groups in months 0–6. As expected, cancer patients with VTE had significantly worse mortality at six months and one year compared to cancer patients with AF. Conclusion Patients receiving chronic warfarin therapy who are newly diagnosed with cancer experience a significant decrease in TTR in the first 6 months after diagnosis, regardless of indication for anticoagulation. This effect appears to attenuate in months 7–12. |
Databáze: | OpenAIRE |
Externí odkaz: |