The Concentration of CMKLR1 Expression on Clinicopathological Parameters of Colorectal Cancer: A Preliminary Study

Autor: Maciej Kajor, Elżbieta Świętochowska, Alicja Prawdzic Seńkowska, Magdalena Chrabańska, Sylwia Mielcarska, Miriam Dawidowicz, Janusz Jopek, Magdalena Rynkiewicz, Jerzy Piecuch, Dariusz Waniczek, Paweł Kiczmer, Agnieszka Kula
Rok vydání: 2021
Předmět:
Zdroj: Medicina
Medicina, Vol 57, Iss 1299, p 1299 (2021)
Medicina; Volume 57; Issue 12; Pages: 1299
ISSN: 1648-9144
Popis: Background and Objectives: Colorectal cancer (CRC) is the second-most common cause of cancer-related deaths worldwide. Angiogenesis is crucial for cancer growth, infiltration of surrounding tissues, and metastasis and plays a key role in the pathogenesis of CRC. Chemerin/chemokine-like receptor 1 (CMKLR1) is one of the biochemical pathways involved in the regulation of angiogenesis in solid tumors. The aim of the study was to assess the CMKLR1 level in tumor and margin tissues of CRC in relation to histopathological parameters: microvessel density (MVD), budding, tumor-infiltrating lymphocytes (TILs), TNM scale, and grading. Materials and Methods: The study involved 43 samples of tumor and margin tissues obtained from CRC patients. To assess the concentration of CMKLR1 a commercially available enzyme-linked immunosorbent assay kit was used. For 35 cases, we performed CD34 immunostaining. The MVD, budding, and TILs were assessed using a light microscope. Results: The levels of CMKLR1 in both tumor and margin were negatively correlated with MVD and budding. CMKLR1 concentration in margin was higher in tissues with lymphocytic infiltration. Conclusions: Low vascularity and low budding are associated with higher CMKLR1 expression. CMKLR1 might play a multifunctional role in CRC pathogenesis by influencing tumor budding and peritumoral lymphocytic infiltration.
Databáze: OpenAIRE
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