Correlation of von Willebrand factor and platelets with acute ischemic stroke etiology and revascularization outcome: an immunohistochemical study
| Autor: | Oana Madalina Mereuta, Mehdi Abbasi, Jorge L Arturo Larco, Daying Dai, Yang Liu, Santhosh Arul, Ramanathan Kadirvel, Ricardo A Hanel, Albert J Yoo, Mohammed A Almekhlafi, Kennith F Layton, Josser E Delgado Almandoz, Peter Kvamme, Vitor Mendes Pereira, Babak S Jahromi, Raul G Nogueira, Matthew J Gounis, Biraj Patel, Amin Aghaebrahim, Eric Sauvageau, Parita Bhuva, Jazba Soomro, Andrew M Demchuk, Ike C Thacker, Yasha Kayan, Alexander Copelan, Pouya Nazari, Donald Robert Cantrell, Diogo C Haussen, Alhamza R Al-Bayati, Mahmoud Mohammaden, Leonardo Pisani, Gabriel Martins Rodrigues, Ajit S Puri, John Entwistle, Alexander Meves, Luis Savastano, Harry J Cloft, Shahid M Nimjee, Robert D McBane, David F Kallmes, Waleed Brinjikji |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of NeuroInterventional Surgery. 15:488-494 |
| ISSN: | 1759-8486 1759-8478 |
| Popis: | BackgroundPlatelets and von Willebrand factor (vWF) are key components of acute ischemic stroke (AIS) emboli. We aimed to investigate the CD42b (platelets)/vWF expression, its association with stroke etiology and the impact these components may have on the clinical/procedural parameters.MethodsCD42b/vWF immunostaining was performed on 288 emboli collected as part of the multicenter STRIP Registry. CD42b/VWF expression and distribution were evaluated. Student’s t-test and χ2test were performed as appropriate.ResultsThe mean CD42b and VWF content in clots was 44.3% and 21.9%, respectively. There was a positive correlation between platelets and vWF (r=0.64, pConclusionsThe vWF level and CD42b/vWF distribution pattern in emboli were correlated with AIS etiology and revascularization outcome. Platelet content was associated with response to thrombolysis. |
| Databáze: | OpenAIRE |
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