Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality
| Autor: | P.J. Lundberg, Katarzyna Góralczyk, V. Zviezdai, Leon J. S. Brokken, M. Spanò, Gunnar Toft, H.S. Pedersen, Jens Peter Bonde, Bo Jönsson, Gian Carlo Manicardi, Paweł Struciński, Y. Lundberg Giwercman, Aleksander Giwercman |
|---|---|
| Přispěvatelé: | Spanò, M. |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Genetic association studies Cross-sectional studies Gene–environment interaction Single nucleotide polymorphism Aryl hydrocarbon receptor Dichlorodiphenyl Dichloroethylene Repressor Single-nucleotide polymorphism Aryl hydrocarbon receptor repressor DNA Fragmentation Toxicology Polymorphism Single Nucleotide Semen quality Semen Internal medicine medicine Humans Gene-environment interaction DNA damage Inhibins Cross-sectional studie biology Environmental Exposure Sperm Polychlorinated Biphenyls Spermatozoa Hedgehog signaling pathway Chromatin Repressor Proteins Semen Analysis Endocrinology Genetic association studie Receptors Aryl Hydrocarbon biology.protein Environmental Pollutants Signal Transduction |
| Zdroj: | Europe PubMed Central Brokken, L J S, Lundberg, P J, Spanò, M, Manicardi, G C, Pedersen, H S, Struciński, P, Góralczyk, K, Zviezdai, V, Jönsson, B A G, Bonde, J P, Toft, G, Lundberg Giwercman, Y & Giwercman, A 2014, ' Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality ', Reproductive toxicology (Elmsford, N.Y.), vol. 49C, pp. 65-73 . https://doi.org/10.1016/j.reprotox.2014.07.073 |
| ISSN: | 1873-1708 |
| DOI: | 10.1016/j.reprotox.2014.07.073 |
| Popis: | Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene-environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) are associated with 21 parameters of male reproductive function in 581 proven-fertile European and Greenlandic men. In Greenlandic men, AHR variants significantly modified the association between serum levels of both p,p'-DDE and CB-153 and inhibin B levels, sperm chromatin integrity, and seminal zinc levels. In the total cohort, interactions between AHRR variants and serum levels of CB-153 were associated with sperm chromatin integrity and the expression of the pro-apoptotic marker protein Fas. The data indicate that susceptibility to adverse effects of POP exposure on male reproductive function is dependent on polymorphisms in genes involved in AHR signalling. © 2014 Elsevier Inc. |
| Databáze: | OpenAIRE |
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