Individuals at risk for rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential
| Autor: | Marie L. Feser, V. Michael Holers, Mihnea R. Mangalea, Breck A. Duerkop, Meagan E. Chriswell, Kevin D. Deane, Karthik Anantharaman, Jennifer Seifert, Alexandra Sakatos, David Paez-Espino, Anushila Chatterjee, Kristine A. Kuhn, Kristopher Kieft, M. Kristen Demoruelle |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male musculoskeletal diseases Disease Microbiology Anti-Citrullinated Protein Antibodies Serology Arthritis Rheumatoid Bacteriophage 03 medical and health sciences 0302 clinical medicine Risk Factors Virology medicine Humans Bacteriophages Microbiome skin and connective tissue diseases Bacteroidaceae Phylogeny Aged 030304 developmental biology Autoimmune disease 0303 health sciences biology Microbiota Lachnospiraceae Middle Aged medicine.disease biology.organism_classification Intestines Immunology biology.protein Female Parasitology Antibody 030217 neurology & neurosurgery |
| Zdroj: | Cell Host & Microbe. 29:726-739.e5 |
| ISSN: | 1931-3128 |
| Popis: | Rheumatoid arthritis (RA) is an autoimmune disease characterized in seropositive individuals by the presence of anti-cyclic citrullinated protein (CCP) antibodies. RA is linked to the intestinal microbiota, yet the association of microbes with CCP serology and their contribution to RA is unclear. We describe intestinal phage communities of individuals at risk for developing RA, with or without anti-CCP antibodies, whose first-degree relatives have been diagnosed with RA. We show that at-risk individuals harbor intestinal phage compositions that diverge based on CCP serology, are dominated by Streptococcaceae, Bacteroidaceae, and Lachnospiraceae phages, and may originate from disparate ecosystems. These phages encode unique repertoires of auxiliary metabolic genes, which associate with anti-CCP status, suggesting that these phages directly influence the metabolic and immunomodulatory capability of the microbiota. This work sets the stage for the use of phages as preclinical biomarkers and provides insight into a possible microbial-based causation of RA disease development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|