High ovarian response to ovarian stimulation: effect on morphokinetic milestones and cycle outcomes
| Autor: | Gilad Karavani, Tamar Wainstock, Natali Schachter-Safrai, Iris Har-Vardi, Eliahu Levitas, Efrat Esh-Broder, Assaf Ben-Meir |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Pregnancy Rate Cleavage Stage Ovum Embryonic Development Oocyte Retrieval Fertilization in Vitro Andrology Embryo Culture Techniques Young Adult Human fertilization Ovulation Induction Pregnancy Genetics medicine Humans Blastocyst Embryo Implantation Sperm Injections Intracytoplasmic Assisted Reproduction Technologies Genetics (clinical) Retrospective Studies Pronucleus business.industry Ovary Obstetrics and Gynecology Embryo General Medicine Blastomere Oocyte medicine.disease Polycystic ovary medicine.anatomical_structure Reproductive Medicine Oocytes Female business Developmental Biology Polycystic Ovary Syndrome |
| Zdroj: | J Assist Reprod Genet |
| Popis: | PURPOSE: To assess the effect of high ovarian response on oocyte quality and ovarian stimulation cycle outcomes. METHODS: A retrospective cohort study conducted at three IVF units. The high ovarian response (HOR) and polycystic ovary syndrome (PCOS) with HOR (PCOS HOR) groups included 151 and 13 women who underwent controlled ovarian stimulation (COS) resulting in more than 15 retrieved oocytes, for a total of 1863 and 116 cultured embryos, respectively. The normal ovarian response (NOR) group comprised 741 women with 6–15 retrieved oocytes, resulting in 4907 cultured embryos. Data collected included fresh cycle data and pregnancy rates, in addition to annotation of morphokinetic events from time of pronuclei fading to time of initiation of blastocyst formation of embryos cultured in a time lapse incubator, including occurrence of direct unequal cleavage at first cleavage (DUC-1) (less than 5 h from two to three blastomeres). Comparison was made between morphokinetic parameters between the 3 groups. Cycle outcomes were compared in the high vs. normal ovarian response groups. RESULTS: Oocyte maturation rate was significantly lower in the HOR vs. NOR groups (56.5% vs. 90.0%, p |
| Databáze: | OpenAIRE |
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