Synthesis of substituted imidazopyrazines as ligands for the human somatostatin receptor subtype 5
| Autor: | Christophe Thurieau, Barry A. Morgan, Pierre Roubert, Christophe Moinet, Lydie Poitout, Thomas D. Gordon, Marie-Odile Contour-Galcera |
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| Rok vydání: | 2001 |
| Předmět: |
Agonist
Stereochemistry medicine.drug_class Clinical Biochemistry Pharmaceutical Science CHO Cells Ligands Biochemistry Chemical synthesis Cricetinae Drug Discovery medicine Animals Combinatorial Chemistry Techniques Humans Protein Isoforms Receptors Somatostatin Molecular Biology Molecular Structure Bicyclic molecule Chemistry Somatostatin receptor Organic Chemistry Imidazoles Combinatorial chemistry In vitro Pyrazines Molecular Medicine Protein Binding |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 11:741-745 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)00051-8 |
| Popis: | A new preparation of trisubstituted imidazopyrazines and dihydroimidazopyrazines via parallel synthesis using aminoacids and bromoketones resulted in the discovery of non-peptidic sst5 selective agonists. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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