Nanog Expression and Proliferation Indices in Canine Cutaneous Mast Cell Tumors
| Autor: | Julia Antongiovanni Joselevitch, Ricardo de Francisco Strefezzi, José Guilherme Xavier, Camila Neri Barra, Lidia Hildebrand Pulz, José Luiz Catão-Dias, Silvia Regina Kleeb, Adriana Tomoko Nishiya, Thiago Henrique Moroni Vargas |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Homeobox protein NANOG Male Mitotic index Skin Neoplasms 03 medical and health sciences 0302 clinical medicine Dogs Cancer stem cell MASTOCITOMA ANIMAL medicine Biomarkers Tumor Animals Dog Diseases Cell Proliferation General Veterinary biology Nanog Homeobox Protein Mastocytoma medicine.disease Mast cell Prognosis 030104 developmental biology medicine.anatomical_structure Ki-67 Antigen 030220 oncology & carcinogenesis Ki-67 biology.protein Cancer research Immunohistochemistry |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1544-2217 |
| Popis: | Mast cell tumors are one of the most frequent skin tumors in dogs. Treatment decisions often depend on a wide range of clinical information and the main criteria for prognostic formulation are histological grade, mitotic count, Ki67 index, and KIT immunostaining pattern. NANOG is a pluripotency factor expressed by normal and cancer stem cells, which is a prognostic marker and a potential therapeutic target for several human tumors. In the present study, mast cell tumor samples from 41 dogs were evaluated for NANOG and Ki67 by immunohistochemistry. All samples were positive for NANOG but its expression was not correlated with Ki67 index and no significant differences were found with respect to histopathological grades, disease-related mortality, or survival. Our results suggest that, although related to pluripotency, NANOG expression does not correlate with proliferative activity, and is not a reliable prognostic factor for canine cutaneous mast cell tumors. |
| Databáze: | OpenAIRE |
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