Increased Incidence of Stroke, but Not Coronary Heart Disease, in Elderly Patients With Sleep Apnea Role of Continuous Positive Airway Pressure Treatment
| Autor: | Francisco Campos-Rodriguez, Cristina Navarro-Soriano, Pablo Catalan-Serra, Juan-José Soler-Cataluña, Pilar Román-Sánchez, Carmen V Almeida-González, Nuria Reyes-Nuñez, Miguel Ángel Martínez-García, Marta Ballester-Canelles, Maria Jose Selma-Ferrer |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Continuous positive airway pressure 030204 cardiovascular system & hematology coronary disease 03 medical and health sciences 0302 clinical medicine stomatognathic system Interquartile range Internal medicine Post-hoc analysis medicine sleep apnea syndromes Stroke Sleep apnea syndromes Advanced and Specialized Nursing Coronary disease business.industry Incidence (epidemiology) Hazard ratio Sleep apnea medicine.disease stroke nervous system diseases respiratory tract diseases cardiovascular diseases Obstructive sleep apnea Cardiovascular diseases Neurology (clinical) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery continuous positive airway pressure |
| Zdroj: | Stroke r-FISABIO. Repositorio Institucional de Producción Científica instname r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe Digital.CSIC. Repositorio Institucional del CSIC |
| ISSN: | 1524-4628 0039-2499 |
| Popis: | [Background and Purpose] The influence of age on the relationship between obstructive sleep apnea (OSA) and the incidence of hard cardiovascular events remains controversial. We sought to analyze the relationship between OSA and the incidence of stroke and coronary heart disease in a large cohort of elderly patients, as well as to investigate the role of continuous positive airway pressure (CPAP) treatment in these associations. [Methods] Post hoc analysis of a prospective observational study of consecutive patients ≥65 years studied for OSA suspicion at 2 Spanish University Hospitals. Patients with an apnea-hypopnea index (AHI) [Results] 859 and 794 elderly patients were included in the stroke and coronary heart disease analyses, respectively. The median (interquartile range) follow-up was 72 (50–88.5) and 71 (51.5–89) months, respectively. Compared with the reference group, the fully adjusted hazard ratios for the incidence of stroke were 3.42 (95% CI, 1.37–8.52), 1.02 (95% CI, 0.41–2.56), and 1.76 (95% CI, 0.62–4.97) for the untreated severe OSA group, CPAP-treated group, and untreated mild-moderate OSA group, respectively. No associations were shown between any of the different OSA groups and coronary heart disease incidence. [Conclusions]The incidence of stroke, but not coronary heart disease, is increased in elderly patients with untreated severe OSA. Adequate CPAP treatment may reduce this risk. |
| Databáze: | OpenAIRE |
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