Methionine transsulfuration pathway is upregulated in long-lived humans
| Autor: | Joaquim Sol, Consuelo Borrás, José Daniel Galo-Licona, Reinald Pamplona, Mariona Jové, Josep Puig, Jose Viña, Rebeca Berdún, Irene Pradas, Èlia Obis, Natalia Mota-Martorell, Rosanna Cabré |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
media_common.quotation_subject Longevity Transsulfuration pathway Biology Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Methionine Downregulation and upregulation Tandem Mass Spectrometry Physiology (medical) Humans media_common chemistry.chemical_classification Aged 80 and over Metabolism Phenotype Amino acid 030104 developmental biology chemistry Metabolome 030217 neurology & neurosurgery Homeostasis Chromatography Liquid |
| Zdroj: | Free radical biology & medicine r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname |
| ISSN: | 1873-4596 |
| Popis: | Available evidences point to methionine metabolism as a key target to study the molecular adaptive mechanisms underlying differences in longevity. The plasma methionine metabolic profile was determined using a LC-MS/MS platform to systematically define specific phenotypic patterns associated with genotypes of human extreme longevity (centenarians). Our findings demonstrate the presence of a specific plasma profile associated with human longevity characterized by an enhanced transsulfuration pathway and tricarboxylic acid (TCA) cycle intermediates, as well as a reduced content of specific amino acids. Furthermore, our work reveals that centenarians maintain a strongly correlated methionine metabolism, suggesting an improved network integrity, homeostasis and more tightly regulated metabolism. We have discovered a particular methionine signature related to the condition of extreme longevity, allowing the identification of potential mechanisms and biomarkers of healthy aging. |
| Databáze: | OpenAIRE |
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