Serum Levels of Soluble Adhesion Molecules Intercellular Adhesion Molecule 1, Vascular Cell Adhesion Molecule 1, and E-selectin in Patients With Wegener's Granulomatosis. Relationship to Disease Activity and Relevance During Followup

Autor: Coen A. Stegeman, Jwc Tervaert, de Paul Jong, Cornelis Kallenberg, Minke G. Huitema
Jazyk: angličtina
Rok vydání: 1994
Předmět:
Male
Systemic disease
SYSTEMIC LUPUS-ERYTHEMATOSUS
chemistry.chemical_compound
Immunology and Allergy
Pharmacology (medical)
Interferon gamma
Respiratory Tract Infections
TUMOR-NECROSIS-FACTOR
VCAM-1
Membrane Glycoproteins
biology
Cell adhesion molecule
CYTOPLASMIC ANTIBODY TITER
CIRCULATING ICAM-1
Bacterial Infections
Middle Aged
Intercellular Adhesion Molecule-1
Virus Diseases
Female
E-Selectin
Soluble Vascular Cell Adhesion Molecule 1
medicine.drug
Adult
EXPRESSION
medicine.medical_specialty
Adolescent
Immunology
LEUKOCYTE ADHESION
Vascular Cell Adhesion Molecule-1
Enzyme-Linked Immunosorbent Assay
Rheumatology
Internal medicine
E-selectin
medicine
Humans
Aged
INTERFERON-GAMMA
Vascular disease
business.industry
Granulomatosis with Polyangiitis
medicine.disease
ENDOTHELIAL-CELLS
RHEUMATOID-ARTHRITIS
Endocrinology
chemistry
Solubility
biology.protein
business
Cell Adhesion Molecules
Follow-Up Studies
Zdroj: ARTHRITIS AND RHEUMATISM, 37(8), 1228-1235. John Wiley and Sons Inc.
ISSN: 0004-3591
DOI: 10.1002/art.1780370818
Popis: Objective. To assess the value of measuring serum levels of soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), and soluble E-selectin for monitoring disease activity in Wegener's granulomatosis (WG).Methods. A sandwich enzyme-linked immunosorbent assay was used to measure levels of soluble adhesion molecules at the time of diagnosis in 22 consecutive patients with WG, in 12 WG patients studied serially prior to disease relapse, at the time of upper airways infection in 18 patients with inactive WG, and in 57 controls. Disease activity was assessed by disease activity score and C-reactive protein levels.Results. At diagnosis of WG, sICAM-1 and sVCAM-1 levels were significantly elevated and correlated with disease activity. At the time of relapse, a significant increase in all 3 soluble adhesion molecules was found compared with levels at 6 months prior to relapse, but only sVCAM-1 levels were significantly elevated compared with those in controls. Levels of soluble adhesion molecules at the time of relapse did not differ from those measured during an upper airways infection without disease activity.Conclusion. Elevated serum levels of sICAM-1 and sVCAM-1 can be found in active WG and correlate with disease activity. However, their clinical relevance for followup is limited due to lack of sensitivity and specificity for WG disease activity.
Databáze: OpenAIRE
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