Potential α-glucosidase inhibitor from Hylotelephium erythrostictum
| Autor: | Xiao-Yong Zhang, Si-Hong Wang, Li-Li Jin, Yin-Sheng Quan, Xiu-Mei Yin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Clinical Biochemistry
Pharmaceutical Science Pharmacology Crassulaceae 01 natural sciences Biochemistry chemistry.chemical_compound Catalytic Domain Drug Discovery Humans Hypoglycemic Agents Glycoside Hydrolase Inhibitors Gallic acid Medicinal plants Molecular Biology biology Plant Extracts 010405 organic chemistry Organic Chemistry alpha-Glucosidases biology.organism_classification Diosmetin 0104 chemical sciences Molecular Docking Simulation 010404 medicinal & biomolecular chemistry chemistry Hylotelephium erythrostictum Apigenin Kaempferide Molecular Medicine Kaempferol Quercetin |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 30:127665 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2020.127665 |
| Popis: | In light of the adequate sources for Hylotelephium erythrostictum, its active components have aroused research interest. 2-(3′,4′-dihydroxyphenyl)-2,3-dihydro-4,6-dihydroxy-2-(methoxy)- 3-benzofuranone(1), apigenin(2), diosmetin(3), kaempferol(4), kaempferide(5), rhamnocitrin(6), quercetin(7), and gallic acid(8) were isolated from H. erythrostictum. Rarely occurring naturally, 1 is 2-methoxybenzofuranone type compound against α-glucosidase and exhibits a potential inhibitory effect on α-glucosidase(IC50 = 1.8 μM), with a Ki value of 709 nM. In silico molecular docking was performed for the investigation of the inhibition mechanism. H. erythrostictum is a potential source of antidiabetic agent. This information is useful in finding more potent antidiabetic candidates from medicinal plants for the clinical development of therapeutics. |
| Databáze: | OpenAIRE |
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