Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination
| Autor: | Ivette Casafont, Elisabet Zamora, Antoni Bayes-Genis, Jose Luis Mate, Eva Martínez-Cáceres, Susana Holgado, Elena Seder-Colomina, Bibiana Quirant-Sánchez |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty idiopathic inflammatory myopathy Proximal muscle weakness Myocarditis lcsh:Medicine Case Report 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Cardiac magnetic resonance imaging medicine Anti-SAE antibody 030203 arthritis & rheumatology Lung medicine.diagnostic_test business.industry lcsh:R Skeletal muscle Idiopathic inflammatory myopathy General Medicine Dermatomyositis medicine.disease Dysgeusia medicine.anatomical_structure myocarditis medicine.symptom business Atrioventricular block anti-SAE antibody |
| Zdroj: | Journal of Clinical Medicine, Vol 8, Iss 1, p 20 (2018) Journal of Clinical Medicine Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm8010020 |
| Popis: | A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated a diagnosis of myocarditis, confirmed with cardiac magnetic resonance imaging and endomyocardial biopsy. A comprehensive immune work-up revealed anti-small ubiquitin-like modifier-1 activating enzyme (anti-SAE) antibody, a novel myositis-specific antibody, previously described mainly with overt cutaneous dermatomyositis and late skeletal muscle manifestations. Here, heart–lung–muscle involvement combined with anti-SAE antibodies was a severe combination. |
| Databáze: | OpenAIRE |
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