Organochlorines in Swedish women: determinants of serum concentrations
| Autor: | Fredrik Granath, Per Ola Darnerud, Marie Aune, Rickard Bjerselius, Samuel Atuma, Elisabete Weiderpass, Harri Vainio, Andres Wicklund Glynn |
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| Rok vydání: | 2003 |
| Předmět: |
Insecticides
medicine.medical_specialty Health Toxicology and Mutagenesis Chlordane Body Mass Index chemistry.chemical_compound Risk Factors Diabetes mellitus Internal medicine Diabetes Mellitus medicine Animals Humans Life Style Aged Sweden business.industry Weight change Age Factors Fishes Public Health Environmental and Occupational Health Polychlorinated biphenyl Hexachlorobenzene Middle Aged Pesticide medicine.disease Polychlorinated Biphenyls Diet Epidemiologic Studies Endocrinology chemistry Dichlorodiphenyldichloroethylene Environmental Pollutants Female business Body mass index Research Article |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| DOI: | 10.1289/ehp.5456 |
| Popis: | We studied associations between lifestyle/medical factors and lipid-adjusted serum concentrations of seven polychlorinated biphenyl (PCB) congeners and five chlorinated pesticides/metabolites among 205 Swedish women (54-75 years old). Serum concentrations were significantly associated with age, body mass index, body weight change, diabetes mellitus, consumption of fatty fish, and place of residence. The findings suggest that lifestyle/medical factors may confound results in epidemiologic studies when they are related to both serum concentrations and disease. Moreover, disease itself may influence serum concentrations of some organochlorines, as indicated by the negative associations between recent weight change and serum concentrations of some PCB congeners, p,p -dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) and the positive association between diabetes mellitus and HCB concentrations. Age was the only determinant that showed a consistent association with all compounds studied (positive); otherwise associations with single determinants varied among compounds even within the PCB group. This shows that the studied organochlorines should not be treated as a homogeneous group of compounds in epidemiologic studies. |
| Databáze: | OpenAIRE |
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