Role of oxidative stress, genome damage and DNA methylation as determinants of pathological conditions in the newborn: an overview from conception to early neonatal stage
| Autor: | Alessia Azzarà, Consuelo Micheli, Valentina Colosimo, Paolo Ghirri, Maria Giulia Tozzi, Roberto Scarpato, Carlos Garcia Crespo, Serena Testi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
DNA damage
Health Toxicology and Mutagenesis Oxidative stress Genome damage DNA methylation Mothers Newborns Context (language use) Biology Bioinformatics medicine.disease_cause Genome Epigenesis Genetic Metabolic Diseases Pregnancy Genetics medicine Humans Pathological Neonatal stage Infant Newborn food and beverages Methylation Environmental Exposure DNA Methylation Pregnancy Complications Oxidative Stress DNA methylation Premature Birth Female Oxidative stress DNA Damage |
| Popis: | Increasing evidence suggests that early-life events can predispose the newborn to a variety of health issues in later life. In adverse pre- and perinatal conditions, oxidative stress appears to play an important role in the development of future pathological outcomes. From a molecular point of view, oxidative stress can result in genome damage and changes in DNA methylation that can in turn prime pathogenic mechanisms. Interestingly, both alterations have been related to a reciprocal regulation of oxidative stress. The aim of this review is to give a brief overview of the complex relationship linking oxidative stress to DNA damage and methylation and to go through the different sources of exposure that a neonate can encounter in utero or shortly after birth. In this context, the setup of methodologies to monitor the extent of oxidative stress, genomic damage and instability or the presence of altered methylation patterns contributes to the understanding on how the complex events occurring in early life can lead to either a healthy status or a pathological condition. |
| Databáze: | OpenAIRE |
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