Self-Assembled Multi- and Single-Chain Glyconanoparticles and Their Lectin Recognition
| Autor: | Yamin Abdouni, Anja R. A. Palmans, Carlos Redondo-Gómez, Alessandra Monaco, Gijs M. ter Huurne, E. W. Meijer, C. Remzi Becer, Gokhan Yilmaz |
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| Přispěvatelé: | Macro-Organic Chemistry, Supramolecular Chemistry & Catalysis, ICMS Core, EIRES Chem. for Sustainable Energy Systems, ICMS Business Operations |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Polymers and Plastics
Polymers Radical polymerization Supramolecular chemistry Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Polymerization Biomaterials chemistry.chemical_compound Lectins Amphiphile Materials Chemistry Surface plasmon resonance chemistry.chemical_classification Acrylate Hydrogen bond technology industry and agriculture Polymer Surface Plasmon Resonance 021001 nanoscience & nanotechnology 0104 chemical sciences Folding (chemistry) chemistry Chemical engineering 0210 nano-technology Mannose |
| Zdroj: | Biomacromolecules, 22(2), 661-670. American Chemical Society |
| ISSN: | 1525-7797 |
| Popis: | In this work, we describe the physicochemical characterization of amphiphilic glycopolymers synthesized via copper(0)-mediated reversible-deactivation radical polymerization (Cu-RDRP). Depending on the chemical composition of the polymer, these glycopolymers are able to form multi-chain or single-chain polymeric nanoparticles. The folding of these polymers is first of all driven by the amphiphilicity of the glycopolymers and furthermore by the supramolecular formation of helical supramolecular stacks of benzene-1,3,5-tricarboxamides (BTAs) stabilized by threefold hydrogen bonding. The obtained polymeric nanoparticles were subsequently evaluated for their lectin-binding affinity toward a series of mannose- and galactose-binding lectins via surface plasmon resonance. We found that addition of 2-ethylhexyl acrylate to the polymer composition results in compact particles, which translates to a reduction in binding affinity, whereas with the addition of BTAs, the relation between the nature of the particle and the binding ability system becomes more unpredictable. |
| Databáze: | OpenAIRE |
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