N-Oxide heterocycles and imidazoles replacing ring D of calanolides against Mycobacterium tuberculosis
| Autor: | Xiao-Yong Guo, Zijie Liu, Gang Liu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Natural product
biology Chemistry(all) 010405 organic chemistry Stereochemistry Bioreductive drug Oxide General Chemistry Calanolide A biology.organism_classification Ring (chemistry) 01 natural sciences 0104 chemical sciences Mycobacterium tuberculosis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Mic values Calanolides |
| Zdroj: | Chinese Chemical Letters. 27(1):51-54 |
| ISSN: | 1001-8417 |
| DOI: | 10.1016/j.cclet.2015.11.001 |
| Popis: | We have explored the chemistry of N -oxide heterocycles and imidazoles replacing ring D of the natural product (+)-calanolide A, and have synthesized 12 new analogues, two of which were active against both R Mtb and NR Mtb with MIC values of 12.5 μg/mL, which would lead to further optimization for more potent anti-TB candidates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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