Plasma amyloid-beta forms in Alzheimer's disease and non-Alzheimer's disease patients
| Autor: | Peter Paul De Deyn, Judith J Leurs, Walter W Blomme, Nathalie Le Bastard, Sebastiaan Engelborghs |
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| Přispěvatelé: | Clinical sciences, Neurology |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Amyloid beta Statistics as Topic Future application Disease Gastroenterology Immunoassay/methods Alzheimer Disease Internal medicine Healthy control mental disorders medicine Protein Isoforms Dementia Humans In patient Aged Immunoassay Medicine(all) Amyloid beta-Peptides biology business.industry Alzheimer Disease/blood General Neuroscience Amyloid beta-Peptides/blood Protein Isoforms/blood Diagnostic marker General Medicine Control subjects medicine.disease Peptide Fragments Psychiatry and Mental health Clinical Psychology Dementia/blood Area Under Curve biology.protein Female Human medicine Geriatrics and Gerontology business aged 80 and over Mental Status Schedule Peptide Fragments/blood |
| Zdroj: | Journal of Alzheimer's disease |
| ISSN: | 1387-2877 |
| Popis: | The objective of this study was to evaluate the diagnostic performance of full-length and N-truncated plasma amyloid-beta (Abeta) forms in patients with Alzheimer's disease (AD) and non-Alzheimer's disease dementia (non-AD) as compared to healthy control subjects. Plasma samples from 50 AD, 50 non-AD, and 47 control subjects were included and analyzed using a multiparameter fluorimetric bead-based immunoassay for the simultaneous quantification of different Abeta forms. No significant differences in Abeta isoforms were detected between dementia and controls; or AD, non-AD, and controls. Compared to control subjects, pooled dementia patients (AD and non-AD) and AD patients alone had significantly lower plasma Abeta1-42/AbetaN-42 ratios. In each diagnostic group, all plasma Abeta concentrations were significantly correlated. No significant correlations between plasma Abeta forms and age were found. The low diagnostic performance of cross-sectional plasma Abeta measurements hampers future application as diagnostic markers or screening tools for dementia. CSF biomarker analysis remains superior, although the possible application of longitudinal plasma Abeta measurements as screening tools for dementia remains to be elucidated. |
| Databáze: | OpenAIRE |
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